Impact of SARS-CoV-2 spike stability and RBD exposure on antigenicity and immunogenicity
Abstract The spike protein (S) of SARS-CoV-2 induces neutralizing antibodies and is the key component of current COVID-19 vaccines.The most efficacious COVID-19 vaccines are genetically-encoded spikes with a double proline substitution in the hinge region to stabilize S in the prefusion conformation (S-2P).A subunit vaccine can be a valuable additi